COLO.Science · Shakers & Mixers · Thermo shakers
ALEMADR-MSC thermo shaker incubator with cooling — RT−20 °C to 100 °C, eleven blocks, 200–1500 rpm
The ALEMADR-MSC is a thermo shaker incubator with cooling for microtubes, Eppendorf tubes, PCR plates, ELISA plates and centrifuge tubes up to 50 ml. It cools the block to 20 °C below the room and heats it to 100 °C under PID control, to ≤ ±0.3 °C, while shaking from 200 to 1500 rpm on a 3 mm orbit. AUTO-4 °C holds finished samples cold without anyone standing over the instrument. Product code PRO3907.
Cooling, heating and shaking on one bench position
A thermo shaker that only heats sends every cold step back to the ice bucket or the cold room. The ALEMADR-MSC is a thermo shaker incubator with cooling: the same block runs from 20 °C below room temperature up to 100 °C, so a ligation at 14 °C, an incubation at 37 °C and a heat inactivation at 95 °C all happen in one place. Eleven interchangeable blocks cover 96-well PCR and ELISA plates and tubes from 0.5 ml to 50 ml.
Key characteristics
- Cooling to RT−20 °C and heating to 100 °C, PID controlled to ≤ ±0.3 °C.
- AUTO-4 °C — the block drops to 4 °C at the end of a run and holds samples there.
- Programmable runs — up to 5 temperature set points and up to 99 cycles.
- Auto heating, auto running and auto resume after a power interruption.
- Shaking 200–1500 rpm on a 3 mm orbit.
- Cooling times — ≤ 10 min from 100 °C to 25 °C, ≤ 15 min from RT to RT−20 °C.
- Eleven block formats, from 96 × 0.2 ml down to 6 × 50 ml.
- AC100–240 V — one version for every mains supply.
Suitable for
- Ligation at 14 °C and other reactions that have to stay below room temperature.
- Holding finished samples at 4 °C until someone comes back for them.
- Enzyme and DNA library storage at the bench instead of in a fridge across the room.
- Multi-step protocols: several temperatures and cycles in one programme.
- Laboratories that would otherwise need both a heating thermo shaker and a cooled block.
What the cooling range actually buys you
Below-ambient work is where a thermo shaker incubator with cooling pays for itself. Ligations held at 14 °C, oocytes at 17 °C, finished reactions at 4 °C — done on a heating-only instrument, each of these means an ice bucket that melts, a cold room somebody has to walk to, or a fridge where nothing is being mixed. The ALEMADR-MSC holds any of them on the bench, with shaking, for as long as the protocol runs.
The automation is the second half of it. Up to five temperature set points and ninety-nine cycles run from one programme, auto resume brings the run back after a power cut, and AUTO-4 °C drops the block to 4 °C when the programme ends. That combination is what separates this thermo shaker incubator with cooling from the heating-only version: not only the cold end of the range, but being able to leave a run alone.
Model, product code and identification
The ALEMADR-MSC is supplied as a base unit. Blocks are chosen separately by tube or plate format and are ordered under their own product codes — the same eleven blocks as the heating-only ALEMADR-MS. Quote and order with the COLO product code.
Thermo shaker incubator with cooling, RT−20 °C to 100 °C, 200–1500 rpm, 3 mm orbit, eleven blocks ordered separately.
Technical specifications
| Product code | PRO3907 |
| Product type | Thermo shaker incubator with cooling, dry block |
| Temperature setting range | 0 °C to 100 °C |
| Temperature control range | RT−20 °C to 100 °C |
| Temperature accuracy | ≤ ±0.3 °C |
| Temperature uniformity | ≤ ±0.3 °C |
| Display resolution | 0.1 °C |
| Heating time | ≤ 15 min, from 25 °C to 100 °C |
| Cooling time | ≤ 10 min, from 100 °C to 25 °C |
| Cooling below ambient | ≤ 15 min, from RT to RT−20 °C |
| Sample storage | AUTO-4 °C |
| Multi-point running | up to 5 set points |
| Multi-cycle | up to 99 cycles |
| Automatic operation | auto heating, auto running, auto resume |
| Shaking speed | 200–1500 rpm |
| Orbit | 3 mm |
| Timer | 1 min – 99 min 59 s, or continuous |
| Block options | 11 interchangeable blocks, 0.2 ml to 50 ml |
| Motor | Brushless DC |
| Display | LCD — speed, time and temperature |
| Safety | Over-temperature protection, fault detection with buzzer alarm |
| Power | 150 W |
| Supply voltage | AC100–240 V, 50/60 Hz |
| Fuse | 250 V 3 A Φ5×20 |
| Dimensions (W × D × H) and net weight | 260 × 195 × 150 mm · 7.5 kg |
Operating functions
Cooling and heating
The block is set from 0 °C and controlled from 20 °C below the room up to 100 °C, with 0.1 °C on the display and PID regulation holding ≤ ±0.3 °C across the block. Cooling from 100 °C to 25 °C takes ten minutes or less; reaching RT−20 °C from room temperature takes fifteen minutes or less. Heating from 25 °C to 100 °C takes fifteen minutes or less. Because the cold end is defined relative to the room, a warm laboratory raises the lowest temperature you can reach.
Automation and programmes
A programme can hold up to five temperature set points and repeat up to ninety-nine cycles, so a multi-step protocol runs without anyone resetting the instrument between steps. Auto heating brings the block to temperature before the run, auto running starts it, and auto resume picks the run back up after a power interruption. AUTO-4 °C takes the block down to 4 °C when the programme ends, which is what makes an overnight or unattended finish practical.
Shaking, blocks and timing
Speed is adjustable from 200 to 1500 rpm on a 3 mm orbit, and the timer runs from one minute to 99 minutes 59 seconds or continuously. The block is changed by hand — it lifts out of the seat and the next one drops in, with no tools. Blocks for 5 ml and larger tubes carry their own speed limits, listed in the block table of the technical specification.
Build, motor and safe operation
Inside the ALEMADR-MSC, a thermo shaker incubator with cooling, the drive is a brushless DC motor: no brushes to wear, no service interval, no carbon dust near open samples, and quiet enough that the instrument stays on a working bench. The wells are machined to fit the tube wall, so heat and cold reach the sample through contact rather than through air.
Power is 150 W from AC100–240 V at 50/60 Hz, protected by a 250 V 3 A Φ5×20 fuse. The wide input range means this thermo shaker incubator with cooling has no voltage variant to choose at order — the same instrument runs anywhere. It measures 260 × 195 × 150 mm and weighs 7.5 kg without a block.
Standard delivery
- ALEMADR-MSC base unit of the thermo shaker incubator with cooling.
- Mains cable.
- Operating manual.
- Declaration of conformity and warranty documentation.
Blocks are not part of the base unit — they are ordered separately under their own product codes, according to the tube or plate format. The delivered configuration for a specific order is the one confirmed in the COLO.Science quotation.
Catalogue, technical specification and international links
- ALEMADR-MSC thermo shaker incubator with cooling — technical specification (PDF) — five pages, A4 landscape, with the parameter table and drawings of all eleven blocks.
- Shakers & Mixers overview — thermo shakers, orbital shakers, incubators, rockers, vortex mixers and roller mixers.
- Shakers & Mixers catalogue — model comparison by speed, orbit, temperature range and capacity.
- Shakers and mixers on COLO.Science — our international site.
Applications and operational value
In molecular biology the cold end of the range is what a thermo shaker incubator with cooling gets used for most. Ligations are held at 14 °C, oocytes at 17 °C, and finished reactions at 4 °C until someone collects them. Enzymes and DNA libraries sit at working temperature next to the workstation instead of in a fridge on the other side of the laboratory, and none of it needs an ice bucket that has to be watched.
The warm end of the thermo shaker incubator with cooling covers the usual work: restriction digests, reverse transcription, bead clean-ups and heat inactivation up to 100 °C, all with movement. Because a programme can chain five temperatures and repeat them up to ninety-nine times, a protocol that alternates between a cold hold and a warm step runs end to end without being reset between stages.
The eleven blocks decide what fits: a 96-well PCR plate, a 96-well ELISA plate, or tubes from 0.5 ml to 50 ml. These are the same blocks as on the heating-only model, so a laboratory running both a thermo shaker incubator with cooling and the heating-only one buys a single set of blocks and moves them between the two.
Selection guide
- Do you need below-ambient temperature? If not, the heating-only ALEMADR-MS is the cheaper instrument with a higher top speed. If you do, this is the model.
- Lowest working temperature. The thermo shaker incubator with cooling reaches 20 °C below the room — in a laboratory at 25 °C that is 5 °C, not −20 °C. Check the target against the room.
- Tube or plate format. The block decides what the instrument takes: 96 × 0.2 ml PCR plate, 96-well ELISA plate, 54 × 0.5 ml, 35 × 1.5 ml, 35 × 2.0 ml, a mixed 20 × 1.5 + 15 × 0.5 ml block, 24 × 5 ml, 15 × 10 ml, 12 × 15 ml or 6 × 50 ml.
- Check the block speed, not just the instrument speed. 5 and 10 ml blocks run to 1000 rpm, 15 and 50 ml blocks to 800 rpm, while the instrument itself goes to 1500 rpm.
- Unattended runs. If a protocol finishes outside working hours, AUTO-4 °C and auto resume are the reason to choose a thermo shaker incubator with cooling rather than a heating-only instrument.
Configuration notice
This page is provided for orientation and product selection. It does not replace the binding specification, the delivered configuration, the validation protocol or the acceptance criteria confirmed in the official COLO.Science quotation, proforma invoice or order confirmation. Blocks for this thermo shaker incubator with cooling are manufactured to order: hole layout, hole size and mixed tube formats can be made to the laboratory’s own requirement. Cooling performance is stated relative to room temperature. B2B prices are quoted net, excluding VAT.
Sales and support for international customers
COLO Lab ExpertsPolje ob Sotli 4, SI-3255 Buče, Slovenia
Phone: +386 70 713 437 · Email: sales@colo.si · Web: colo.si
We supply laboratories across Europe directly and through partners. B2B prices are quoted net, excluding VAT.
