COLO-DT1206AT — Automatic Sampling Dissolution System for Tablets & Capsules (12 Vessels)
Overview: automatic dissolution testing for pharmaceutical R&D and QC
COLO-DT1206AT is a 12-vessel automatic sampling dissolution system designed for pharmaceutical research, formulation development, method validation and quality control. It targets reproducible dissolution profiles and high-throughput workflows for tablets, capsules and granules.
The platform combines the dissolution Host (bath temperature + mechanical alignment) with the Sampler workstation (injection-pump sampling, filtration, collection, replenishment and cleaning) to reduce manual steps and improve repeatability.
Compliance orientation: engineered to support USP / ChP referenced requirements and guiding principles for mechanical validation of dissolution apparatus (as described in the technical documentation).
Pharmaceutical workflows: controlled dosing, sampling, filtration and reporting
- R&D and formulation development: generate dissolution profiles, compare formulations and optimize release behavior with stable bath temperature and rotation control.
- Quality control (QC): run parallel tests on 12 vessels and maintain consistent sampling intervals for batch-to-batch verification.
- Automatic dosing + anti-evaporation cover: supports tablets/capsules dosing logic; quick-detachable dosing parts support fast cleaning between runs.
- Automatic sampling + two-stage filtration: 12-channel sampling with online filtration supports direct-to-vial workflows for LC/HPLC analysis (configuration dependent).
- Regulated labs: user permissions and audit-style records are supported via software model (configuration dependent); IQ/OQ/PQ documentation available on request.
Key features: 12 vessels, 6+6 zones, automatic sampling and temperature stability
- 12 vessels / 12 shafts (1000 mL glass vessels) for parallel dissolution testing.
- Dual drive concept (6+6 zones): supports dual solvent or dual-speed workflow logic for comparative testing programs.
- Automatic sampling workstation: injection-pump sampling with independent pipelines; timed point logic supports dense sampling schedules (up to 45 points).
- Online two-stage filtration: supports efficient downstream analytics and reduces manual handling steps.
- Temperature control: water bath heating; RT–45°C with deviation ≤ ±0.2°C; multi-channel monitoring supports verification workflows.
- Mechanical repeatability: positioning/locking + lift concept is designed to reduce station-to-station and run-to-run mechanical variability.
- Paddle & basket methods: designed for common pharmacopeia workflows with method flexibility.
System layout: Host vs Sampler (what each part does)
| Host (dissolution tester) | Controls dissolution mechanics (shaft speed + alignment concept) and water bath temperature for stable, repeatable conditions across 12 positions. |
| Sampler workstation | Executes timed automatic sampling via injection pump, routes samples through filtration, collects into racks, and supports replenishment/cleaning logic. |
| Why it matters | Separating “conditions control” (Host) from “sample handling” (Sampler) reduces operator variability and improves throughput in QC and R&D programs. |
| Output workflow | Structured sampling for dissolution profiles, stability studies and release testing; supports LC/HPLC sample preparation workflows (configuration dependent). |
COLO.SCIENCE KNOWLEDGE
Dissolution testing: USP/Pharmacopeia methods, mechanics and validation logic
Build confident dissolution workflows with clear guidance on paddle vs basket methods, temperature control, mechanical performance checks and documentation logic for regulated pharmaceutical testing.
Technical data: Host + Sampler (working parameters and dimensions)
| Model | COLO-DT1206AT — Automatic Sampling Dissolution System (Host + Sampler) |
| Dissolution vessels | 12 vessels |
| Speed range | 10–300 rpm (6+6 zones; speed error ≤ ±0.3 rpm) |
| Heating | Water bath heating |
| Temperature control | Room temperature–45°C (deviation < ±0.2°C), multi-channel monitoring |
| Sampling method | Injection pump sampling (12 channels) + online filtration |
| Sampling volume | Up to 20 mL (accuracy < ±0.1 mL) |
| Sampling points | Up to 45 points (interval logic configuration dependent) |
| Collection racks | 156-position racks (test tubes / liquid phase bottles) |
| External dimensions | Host: 570 × 940 × 630 mm | Sampler: 640 × 445 × 430 mm |
| Power supply | AC 220 V ± 10%, 50/60 Hz |
| Power | Host: 2.0 kW | Sampler: 0.3 kW |
| Weight | Host: 80 kg | Sampler: 40 kg |
Software & data integrity: users, audit trail and storage (configuration dependent)
- User management: multi-level permissions (administrator / supervisor / operator) and user groups.
- Audit-style tracking: login, operation and experimental records; electronic data protected (per documentation logic).
- Backup & remote: real-time backup via USB or enterprise server; remote viewing/printing via server login.
- Paperless reporting: network printer support; storage on instrument/USB/server; searchable experiment history.
- Remote upgrades: remote OS/software upgrade support (service / configuration dependent).
For regulated environments, confirm exact data integrity and reporting requirements with the COLO team.
Standard delivery: Host + Sampler + documentation (IQ/OQ/PQ on request)
- COLO-DT1206AT Host (12 positions) with lift concept, touch interface and temperature monitoring.
- Sampler workstation with injection-pump sampling, filtration and sample collection racks (workflow dependent).
- Vessels and methods: 1000 mL glass vessels; paddle & basket method sets (typical configuration).
- Dosing + anti-evaporation cover for tablets/capsules workflows (typical configuration).
- Sampling consumables: filter heads and vial/tube racks (scope per quotation).
- Documentation: operating manual, inspection report, certification and warranty card; IQ/OQ/PQ available on request.
Exact delivery scope depends on confirmed workflow (R&D vs QC), sampling schedule and downstream analytics (e.g., LC/HPLC).
Optional: COLO-260DT Mechanical Qualification System (PRO6782)
COLO-260DT is designed to support mechanical verification routines for dissolution systems by combining dedicated metrology tools with workstation software. It can accelerate routine checks and improve consistency across qualification cycles.
- SKU: PRO6782
- Workflow: structured measurement + software logging (Bluetooth real-time transfer supported)
- Services: IQ / OQ / PQ (3Q) support available on request
Technical configuration and regulated-use notice
COLO-DT1206AT systems are configured according to confirmed application requirements (R&D vs QC), sampling schedule, filtration workflow and intended regulatory environment. Final delivered specifications, included components, software functions and qualification documentation (IQ/OQ/PQ) are defined in the official quotation and approved technical documentation. Information presented on this website is for general reference and may be subject to change without prior notice.
