COLO.Science · Technical Specification
COLO-DT1206AT
Automatic Sampling Dissolution System · 12 cups / 12 shafts
High-throughput dissolution testing platform for pharmaceutical
research, formulation development, method validation and quality control.
12 × 1000 mL vessels, water bath heating and temperature control RT–45 °C
with deviation < ±0.2 °C. Speed range 10–300 rpm,
integrated dosing, 12-channel injection-pump sampling, online two-stage filtration,
automatic replenishment and cleaning — built for reproducible USP/ChP workflows.
USP / ChP
Mechanical validation
12 cups
Auto dosing
Auto sampling
Data integrity
6+6 zones
Typical applications: tablets / capsules / granules · dissolution profiling · batch release testing · stability studies
Document type: Technical Specification Sheet · Format: Landscape (Word/Outlook-ready)
Document type: Technical Specification Sheet · Format: Landscape (Word/Outlook-ready)
Instrument
COLO-DT1206AT · automatic sampling dissolution · PRO6781
Address (HQ)
Polje ob Sotli 4
SI-3255, Slovenia
SI-3255, Slovenia
Contact
COLO-DT1206AT · Technical Specification
Document ID: COL-TEC-COLO-DT1206AT-EN
SKU / Product No.: PRO6781
Version: Landscape
Informational technical sheet · Non-binding · Controlled electronic document
SKU / Product No.: PRO6781
Version: Landscape
Informational technical sheet · Non-binding · Controlled electronic document
COLO-DT1206AT · automatic sampling dissolution system technical specification sheet
pharma QC
R&D
method validation
paperless
audit trail
— 12 cups / 12 shafts, 10–300 rpm, RT–45 °C (±0.2 °C), 12-channel injection-pump sampling, 156-position rack
📋 general & performance specifications
| instrument identity | |
|---|---|
| name | Automatic Sampling Dissolution |
| type / model | COLO-DT1206AT (DS-1206AT) |
| sku / product number | PRO6781 |
| dissolution cups quantity | 12 cups (1000 mL glass vessels) |
| 🧭 mechanical alignment (validation relevant) | |
| levelness | ≤ 0.2° |
| verticality of rotation shaft | 90.0° ± 0.5° |
| verticality of dissolution cup | 90.0° ± 0.5° |
| coaxiality cup / shaft | ≤ 2.0 mm |
| swing of rotation shaft | ≤ 0.5 mm |
| swing of rotation basket | ≤ 0.5 mm |
| vibration degree | No obvious vibration |
| 🌀 rotation & drive | |
| rotating shaft speed | 10 – 300 rpm |
| dual zone control | 12 channels divided into 6+6 zones (dual solvent / dual speed workflow) |
| speed error (6+6 mode) | ≤ ±0.3 rpm |
| 🌡️ temperature & heating | |
| heating method | Water bath heating |
| temperature control | Room temperature – 45 °C, deviation < ±0.2 °C |
| temperature monitoring | 12 channels, resolution 0.01 °C |
| 🧪 sampling performance | |
| sampling method | Injection pump sampling |
| sampling channels | 12 |
| maximum sampling volume | 20 mL (sampling accuracy < ±0.1 mL) |
| sampling points quantity | 45 |
| minimum sampling interval | First time 2 minutes, other points 5 minutes |
| filter | Two-stage filter (0.45 µm compatible; HPLC-ready workflow) |
| sampling rack | 156 position test tube rack + 156 liquid phase bottle rack |
| sampling test tube | 10 mL test tube / 2 mL liquid phase bottle |
| ⚡ electrical & dimensions | |
| external dimensions |
Host: 570 × 940 × 630 mm Sampler: 640 × 445 × 430 mm |
| power supply | AC220±10%V, 50/60Hz |
| power | Host: 2.0 kW · Sampler: 0.3 kW |
| weight | Host: 80 kg · Sampler: 40 kg |
| ✅ compliance | |
| standards | USP, ChP + Mechanical Validation Guidelines for dissolution meters |
🧩 system architecture: Host vs Sampler (what is where)
| Host (dissolution tester) | |
|---|---|
| primary role | 12-cup dissolution platform with validation-relevant mechanical alignment and water bath heating |
| drive concept | Dual drive shaft system (6+6 zones) supporting dual solvent / dual speed test designs |
| cup positioning | Automatic center positioning, orientation & locking (centrality change after 1000 unload cycles ≤ 0.3 mm) |
| automatic lifting | Intelligent automatic lifting method; electric lifting column for repeatable head height and shaft centering |
| temperature | RT–45°C control (±0.2°C) with 12-channel monitoring (0.01°C resolution) |
| host power / size / weight | 2.0 kW · 570×940×630 mm · 80 kg |
| Sampler (automatic sampling workstation) | |
| primary role | 12-channel injection-pump sampling, online filtration, sample collection, replenishment and cleaning |
| sampling accuracy | Up to 20 mL, accuracy < ±0.1 mL |
| interval control | First point 2 min; other points 5 min |
| collection workflow | 156-position racks; supports test tubes and liquid phase bottles for LC/HPLC workflows |
| sampler power / size / weight | 0.3 kW · 640×445×430 mm · 40 kg |
⚙️ mechanical & temperature dominance (validation-grade)
| coaxial paddle/basket design | Same host supports paddle method, basket method, rotary cylinder, paddle disc, small cup and immersion pool method; sealing rings at coaxial connections to prevent long-term looseness; switching is fast after initial height positioning. |
| dual-bearing shaft fixation | Rotating shaft top fixation with double bearing design supports long-term vertical and coaxial state during operation. |
| automatic lifting system | Automatic lifting platform keeps head horizontal long-term and reduces mechanical drift risk during continuous experiments. |
| temperature control | Handheld and fixed lifting high-precision probes; temperature control accuracy ≤ ±0.2 °C. |
💊 dosing & anti-evaporation workflow (tablets / capsules / granules)
| dosing device | Integrated automatic dosing and anti-evaporation cover; automatic + manual synchronized dosing supported |
| fast cleaning | Quick detachable dozer enables complete cleaning in ~30 seconds; minimizes residue carryover risk |
| sampling position control | Integrated sampling needle keeps sampling position unchanged during sequences |
🧾 software, user management & integrity (regulatory aligned)
| user management | At least 3 levels (administrator, supervisor, operator); preset 1000 login accounts; groups & role permissions |
| audit trail | Login/operation/experiment/exception records; protected electronic data (non-editable / non-deletable); ~25,000 records |
| backup & remote | USB or enterprise server real-time backup; remote view/print via enterprise server login |
| paperless reports | Network printer; storage on instrument/USB/server; search & print by experiment |
| remote OS upgrade | Supported (remote upgrade services based on customer needs) |
🧪 sampling & filtration (HPLC-ready workflow)
| injection pump sampling | 12-channel injection pump sampling with independent pipelines |
| two-stage filter | Online secondary filtration; filter replacement manual/automatic; compatible with common 0.45 µm filters |
| direct-to-vials | Sampling to liquid vials/tubes; efficient for QC and stability programs |
| replenishment & cleaning | Automatic liquid replenishment + automatic cleaning to stabilize medium volume and reduce manual workload |
🧩 optional: COLO-260DT mechanical qualification system
|
COLO-260DT Mechanical Qualification System (SKU: PRO6782) combines third-party metrology instruments
with workstation software to increase verification frequency and improve integrity.
Bluetooth real-time transmission to PC records and displays parameters quantitatively in real time. 3Q services: IQ / OQ / PQ available. |
📎 COLO.Science knowledge
|
Knowledge hub and documentation base: COLO.Science: colo.science |
📦 standard configuration list (reference scope)
| No. | Description | Qty |
|---|---|---|
| 1 | COLO-DT1206AT Dissolution Tester (SKU: PRO6781) | 1 set |
| Includes (Host) | ||
| 2 | Drive Head, 12 Positions | 1 pc |
| 3 | Automatic lifting device | 1 pc |
| 4 | 8.0 Inch High-Resolution Touch Screen | 1 pc |
| 5 | Temperature monitoring system | 1 ea |
| 6 | Automatic lifting sampling device | 1 ea |
| 7 | Vessel cover | 12 ea |
| 8 | Water tank | 1 ea |
| 9 | 1000 mL Glass Vessel | 12 ea |
| 10 | SS 316L Shaft | 12 ea |
| 11 | SS 316L Paddle Blade | 12 ea |
| 12 | Top for basket with stirring shaft | 12 ea |
| 13 | Basket without cover, 40 Mesh | 12 ea |
| 14 | Mobile temperature sensor (PT100) | 1 ea |
| 15 | Sample delivery tray | 12 ea |
| 16 | Calibration Ball (Φ25 mm) | 12 ea |
| 17 | Accessory rack | 1 ea |
| 18 | Software (data integrity compliant; >1000 accounts; >1000 storage methods) | 1 ea |
| Automatic sampling workstation (Sampler) | ||
| 19 | 8-channel syringe pump with secondary online filtering system | 1 ea |
| 20 | Sample collector, 104 positions | 1 ea |
| 21 | Rack for HPLC vials (1.5 mL) | 1 ea |
| 22 | Glasses (Φ16×100 mm), 49 pcs/box | 4 box |
| 23 | PE filter head (35 µm), 500 pcs/pack | 2 ea |
| Manual sampling device (included for flexibility) | ||
| 24 | PEEK Sampling probe | 12 pc |
| 25 | Manual sampling locator | 1 ea |
| 26 | Sampling probe fixture | 12 pc |
| 27 | Silicone dust plug | 12 pc |
| Documents | ||
| 28 | Installation automated system (including IQ) | 1 ea |
| 29 | Operational Qualification (OQ) | 1 ea |
| 30 | Performance Qualification (PQ) | 1 ea |
| 31 | Operating manual | 1 ea |
| 32 | Inspection report | 1 ea |
| 33 | Certification | 1 ea |
| 34 | Warranty Card | 1 ea |
*Configuration list is a reference scope; final contents are defined by order confirmation and approved quotation.
🔧 technical support: phone / email / remote / on-site
📦 spare parts: dedicated warehouse, key supplier agreements
🛠️ annual maintenance: 1–2 in-depth inspections per year
✅ compliance: USP / ChP + mechanical validation principles
📌 Contact & Support
Headquarters address
Polje ob Sotli 4
SI-3255, Slovenia
For quotation requests, please include your vessel count, sampling schedule (points/intervals),
filter workflow (HPLC vials / tubes) and compliance needs (paperless / audit trail / server backup).
Quick contact
Manufacturer & configuration notice (important):
COLO-DT1206AT systems are supplied in configurations aligned with confirmed application needs and workflow requirements (e.g., tablets/capsules/granules dosing, sampling rack format, filtration workflow, data integrity policies). Therefore, the specifications and included components presented in this document are provided for general information and may represent a typical reference configuration.
For procurement and tender purposes, the only valid and binding specification is the official COLO quotation and the accompanying technical specification that is engineering-approved (issued in writing and signed/authorized by COLO). Any deviations, options, accessory scope and software functions are defined exclusively in that approved quotation package.
COLO-DT1206AT systems are supplied in configurations aligned with confirmed application needs and workflow requirements (e.g., tablets/capsules/granules dosing, sampling rack format, filtration workflow, data integrity policies). Therefore, the specifications and included components presented in this document are provided for general information and may represent a typical reference configuration.
For procurement and tender purposes, the only valid and binding specification is the official COLO quotation and the accompanying technical specification that is engineering-approved (issued in writing and signed/authorized by COLO). Any deviations, options, accessory scope and software functions are defined exclusively in that approved quotation package.